About the Role

Xaira is seeking a highly motivated and detail-oriented Research Associate / Senior Research Associate to join our Genomic Core team with a focus on next-generation sequencing (NGS). The ideal candidate will have hands-on experience with Illumina-based sequencing technologies, including library preparation and sequencer operation. This position offers the opportunity to contribute to a wide range of projects across therapeutic areas, supporting cutting-edge genomics research and technology development.

You will work closely with molecular biologists, computational scientists, and platform teams to generate high-quality sequencing data, implement new workflows, and ensure best practices in data generation and quality control.

Key Responsibilities

• Prepare sequencing libraries for Illumina platforms using methods such as TruSeq, Nextera, and amplicon-based workflows.

• Perform PCR and qPCR-based assays to support library preparation and quality control

• Operate and maintain Illumina sequencers (e.g., MiSeq, NextSeq), including run setup, monitoring, and basic troubleshooting.

• Perform QC of input material and libraries (e.g., Bioanalyzer, TapeStation, Qubit, qPCR) and assess sequencing data quality.

• Support NGS data generation workflows and collaborate with internal teams on project needs.

• Maintain accurate documentation in ELN systems and communicate progress in team settings.

• Assist with troubleshooting experimental issues and improving standard workflows.

• Run basic analysis pipelines (e.g., bcl2fastq, CellRanger) as needed.

Qualifications

• B.S./M.S. in Molecular Biology, Genomics, Biotechnology, or a related field with 0-2 years of laboratory experience, including direct experience in NGS workflows and library preparation

• Proficient in Illumina sequencing library preparation methods for DNA and RNA, with a strong understanding of underlying biochemistry and assay design.

• Experience with PCR and qPCR techniques is required.

• Experience operating Illumina sequencers is strongly preferred.

Preferred

• Exposure to single-cell sequencing workflows (e.g., 10x Genomics).

• Strong attention to detail and ability to execute reproducible benchwork.

• Comfortable working in a fast-paced, collaborative environment.

• Familiarity with QC methods for nucleic acids and libraries.

• Basic understanding of NGS data analysis and sequencing outputs.

• Experience with LIMS or data tracking systems (e.g., Benchling, BaseSpace).

Compensation

We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants. We offer a competitive package that includes base salary, bonus, and equity. The base pay range for this position is expected to be $90,000 - $115,000 annually; however, the base pay offered may vary depending on the market, job-related knowledge, skills and capabilities, and experience.

Xaira Therapeutics an equal-opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end.

TO ALL RECRUITMENT AGENCIES: Xaira Therapeutics does not accept agency resumes. Please do not forward resumes to our jobs alias or employees. Xaira Therapeutics is not responsible for any fees related to unsolicited resumes.