Company info

NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.

Description

NewLimit is seeking an Senior/Research Associate with experience in endothelial cell biology to join our Vascular therapeutic team. Our Vascular program is developing reprogramming medicines to restore youthful function in aged endothelial cells for the treatment of renal, cardiometabolic, and cognitive diseases.

Your role will focus on supporting the development of assays and pre-clinical models to measure the functional decline that occurs in endothelial cells with age. You will collaborate closely with our scientists as well as our technology-focused teams to help create the first reprogramming medicines for the vascular tissue.

What you’ll do

In your role as a Senior/Research Associate, you will:

• Execute and optimize functional assays and pre‑clinical models to measure endothelial cell function
• Collaborate with our Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test epigenetic reprogramming interventions at scale
• Measure the impact of mRNA reprogramming medicines on endothelial cell function
• Support the development of in vivo nucleic acid delivery methods for endothelial cells
• Analyze and interpret experimental data to drive pre-clinical decision making

Requirements

• Bachelor’s degree in cell biology, molecular biology, biochemistry or a related field with 2‑5 years of relevant industry or academic experience
• Proficiency in primary mammalian cell culture
• Proficiency in molecular biology techniques (e.g. PCR, gel electrophoresis, molecular cloning)
• Exceptional organizational skills, as demonstrated by detailed record-keeping in a lab notebook and an ability to effectively carry out multiple ongoing projects or experiments

Nice to have

• Experience with isolation and functional characterization of primary endothelial cells
• Experience developing animal models of endothelial cell dysfunction and/or injury
• Experience using computational tools to automate routine data analysis (e.g. Python, R, etc.)
• Experience with pooled screening approaches using bulk or single cell read-outs

Benefits

NewLimit offers generous benefits to ensure our team can focus on our mission:

• Health, dental, and vision insurance
• 401(k) with company match
• Paid parental leave
• Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
• Meals and snacks on-site